Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits
Fig 5
Facilitating mossy fiber inputs generate rapid and stable ensemble formation.
A) Schematic showing the network properties of the spiking network model and long-term plasticity rules. Left: A population of excitatory (red) and inhibitory (blue) cells with all-to-all connectivity and mossy fiber input (gray). Right: Recurrent excitatory CA3-CA3 spike timing-dependent plasticity rule with a symmetric window that shifted from potentiation for correlated spiking at low rates (Ρpost = 0), to depression for uncorrelated spiking near the maximum postsynaptic firing rate (Ρpost = Ρmax). B) Comparison of mossy fiber to irregular ‘perforant path’ input. Synaptic weight evolution with time for CA3-CA3 recurrent connections (red) and inhibitory to excitatory connections (blue) for a two cell excitatory population (top), a 10 cell excitatory population (middle) and a population including 10 excitatory and 5 inhibitory cells (bottom).