Drug-induced resistance evolution necessitates less aggressive treatment
Fig 6
Schematic illustration of the model.
A A minimal model for drug resistance distinguishes sensitive (S) and resistant (R) cells, which follow their own birth-death processes. A treatment can be used to target sensitive cells, but sensitive cells can become resistant via rescue mutations. B Specification of dose-dependent death and mutation rates. We analyse a Hill-type pharmacondynamics and linear dose-dependent mutation rate, but any pharmacodynamics with finite control leverage and monotonically increasing mutation rate will lead to qualitatively similar results reported here. The dashed lines denote the growth inhibitory drug concentration.