Systematic inference of indirect transcriptional regulation by protein kinases and phosphatases
Fig 4
A summary of d(P, T) edges is shown in (A). Counts of inferred edges for each combination of regulation mode for d(PK, T) or d(PP, T) to either a primary transcriptional activator or repressor. Counts statistically larger than expected are marked with asterisk. The top scoring d(P, T) edges with shared GO terms are shown in (B). The number of GO terms shared between secondary regulators and TFs are shown next to each edge. A dashed line indicates the edges was present in the evaluation set, i.e. known interactions. An asterisk on the shared GO term indicates a prediction with no known evidence. Boxes represent regulons for the TFs and are labeled with representative significant biological process GO terms or the process the TF is known to regulate. The size of the box represents the number of genes in the regulon.