Hybrid computational modeling demonstrates the utility of simulating complex cellular networks in type 1 diabetes
Fig 9
Probability of developing T1D based upon combinations of proposed therapeutic strategies.
Therapeutic interventions were implemented based upon single dosage regimens starting at week 4 (Panels A1-A3) to week 16 (Panels D1-D3). Therapy 1 represents a certain strategy that reduces the residence of CTLs in islets. Therapy 2 is described as an intervention that can inhibit DC infiltration into islets. Therapy 3 denotes a strategy that prohibits binding sites on DCs for naïve CD8+ T cells.