Hybrid computational modeling demonstrates the utility of simulating complex cellular networks in type 1 diabetes
Fig 8
Probability of developing T1D based upon different targeted therapeutic strategies.
The horizontal axes represent the administered time of a single dosage during simulation runs. Regions with red color represent a higher incidence of diabetes, and regions with blue color represent a lower incidence of diabetes. (A) Therapy 1 denotes the strategy that reduces the longevity of CTLs in islets. (B) Therapy 2 is described as an intervention that inhibits DC infiltration into islets. (C) Therapy 3 denotes a strategy that mitigates the binding process of naïve CD8+ T cells on DCs. Therapeutic interventions were implemented based upon single dosage regimens starting at week 4 to week 16. Two black circles filled white in Panel (A) show the change in T1D occurrence in Therapy 1 when the lifespan of CTLs was reduced from 120 hours to 114 hours at week 8.