ISOTOPE: ISOform-guided prediction of epiTOPEs in cancer
Fig 4
Splicing epitopes in small cell lung cancer.
(A) Mutation burden (y axis) calculated separately for introns (INTRON), coding exons (CDS) and non-coding exonic regions in protein-coding genes (UTR) calculated from whole genome sequencing (WGS) data for several tumor types (x axis), including small cell lung cancer (SCLC). We indicate the pairs of distributions that were significantly different using a Wilcoxon test (* p-val <0.05, ** p-val <0.01, *** p-val<0.001, **** p-val<0.0001). (B) Number of splicing alterations (y axis) according to event type (x axis), indicating all alterations and the subset that impact the open reading frame (ORF). (C) Distribution of splicing-derived neoepitopes (splicing-neoepitopes) and splicing-affected self-epitopes (self-epitopes), separated by splicing alteration type. (D) Same as (C) but separated by HLA-type.