Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV
Fig 5
Binding free energy distributions of VRC01GL and VRC01 against a panel of 106 HIV antigens (Ags), using the scoring function developed in this work.
A black dashed line indicates the threshold of -9.9 kcal/mol used to determine the breadth (B) of the BCRs. Note that the intermediate-colored region arises from the overlap of the two distributions.