Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV
Fig 4
Results from AM simulations: mean weighted degree of interfacial composition and electrostatic pattern matching (ICM) of all 1-, 2-, or 3-Ag protocols, sorted by the mean ICM score.
Error bars represent the standard deviation of two independent simulations of each vaccination protocol (except for the KR-KR-KR and HQ-EU-WT protocols, for which only one successful trial could be obtained), consisting of between one and three immunizations/GC reactions. Gray and black dotted lines indicate the respective values for VRC01GL and VRC01.