Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV
Fig 2
(A) mean BCR breadth of vaccination protocols with t = 1, 2, and 3 single-Ag sequential immunizations, (B) mean BCR breadth vs. mean number of GC cycles, (C) changes in mean BCR breadth vs. changes in frustration between current (t) and former (t-1) immunizations, and (D) mean BCR breadth vs. mean number of mutations towards conserved Ag residues. In (C), linear fits were used to calculate the R2 values presented in the table below the graph. Error bars represent the standard deviation of two independent simulations of each vaccination protocol (except for the KR-KR-KR and HQ-EU-WT protocols, for which only one successful trial could be obtained), consisting of between one and three immunizations/GC reactions (error bars for mean BCR breadth are only shown in (A) for clarity).