Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variants
Fig 6
Epitope residue conservation in SARS-CoV-1 by antibody cluster.
(A) Epitope conservation, defined as the fraction of RBD epitope residues (< 5 Å distance to antibody) conserved between SARS-COV-1 and SARS-COV-2, was calculated for 70 antibody-RBD complex structures, and conservation values are shown as a boxplot grouped by antibody clusters, with all conservation values shown as points. The outlier point for Cluster 3 (S304 antibody) is labeled, and the total numbers of points are 17 (Cluster 1), 32 (Cluster 2), 9 (Cluster 3), and 12 (Cluster 4). (B) Conserved RBD residues are highlighted on the RBD structure, with conserved RBD residues shown as orange and non-conserved residues gray, and represented as in Fig 3A with antibody cluster paratopes as spheres.