Conventional measures of intrinsic excitability are poor estimators of neuronal activity under realistic synaptic inputs
Fig 3
The model neurons reproduce the firing responses and the physiological diversity of the biological neurons observed in the experiments.
(A, B, C) Voltage responses of the regular, delayed and stuttering type models driven by current step stimulation. Blue traces show the first spike responses just above rheobase levels. (D, F, H) Spike count vs. current plots and (E, G, I) first spike latency plotted as the function of the injected current are shown for the regular, delayed and stuttering type model neurons. Note that the stuttering model exhibits a sudden jump in spike count at the transition to repetitive firing (+195 pA, H). (J) Input membrane resistance vs. resting membrane potential of all model instances. (K) The threshold AMPA-conductance is plotted against the rheobase of the model neurons. (L) Cumulative spike counts from synaptic vs. current step responses are scatter plotted. Data from 600 model instances are shown.