Reconstructing contact network structure and cross-immunity patterns from multiple infection histories
Fig 1
Diagram illustrating the workflow for reconstruction of network properties and immunological interference.
In the first step, we obtain multiple infections histories of individual hosts from our simulator. Second, we calculate similarity metrics between hosts based on their multiple infection histories. Third, by comparing with simulated networks, we determine statistical associations between infection history similarity and contact network adjacency. Fourth, by calculating occurrences of infection overlaps across multiple infection histories, we obtain a matrix of immunological interference between pathogens.