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Inactivation mode of sodium channels defines the different maximal firing rates of conventional versus atypical midbrain dopamine neurons

Fig 10

Single Compartment Dopamine Neuron Model.

A. Circuit diagram of one compartment model with leak, sodium (NaV 1.2), delayed rectifier potassium, A-type potassium (Kv4.3), Calcium activated potassium (SK), L and N type calcium channels, and an HCN channel. B. Calcium balance. Calcium is dynamically buffered using the mechanisms from [62]. The volume was restricted to that of a single submembrane shell (0.5 μm thick) to approximate a dendritic calcium response.

Fig 10

doi: https://doi.org/10.1371/journal.pcbi.1009371.g010