Inactivation mode of sodium channels defines the different maximal firing rates of conventional versus atypical midbrain dopamine neurons
Fig 9
Statistical Summary of Experimental Results.
A. Pacemaker frequency. B. Spike threshold as defined by 5 mV/ms rise rate during pacing. C. Spike width at threshold from B. D. Peak rate of depolarization during pacing (V/s) E. Peak rate of repolarization during pacing. F. Minimum AHP (mV) during pacing. G. Sag potential following hyperpolarization to -80 mV. H. Rebound delay (s) following hyperpolarization from G. I. Peak frequency (Hz) at first observed entry into depolarization block (25 pA intervals). J. Amplitude of evoked response to 75 pA, 200 ms pulse at 1.5 seconds into depolarizing pulse from I. K. Peak dV/dt for evoked response to 200 ms pulse from J. L. All lateral projecting, but only some medial projecting cells clear 5 mV/ms spike threshold. N = 13 for medial shell projecting (red), N = 7 for lateral shell projecting (blue).