Inactivation mode of sodium channels defines the different maximal firing rates of conventional versus atypical midbrain dopamine neurons
Fig 5
Calibration of Long-term Sodium Channel Inactivation of Conventional Model Dopamine Cells Compared to Atypical Model.
Fit of long-term inactivation to data. The protocol of [15] consisting of five brief voltage clamp steps was used to calibrate the conventional model (black dots) and compare to the data taken from [15] (blue diamonds). The red squares are the prediction for the atypical cells. The maximum rate of the I1 to I2 transition was increased to 100 s-1 for conventional from 26.7 s-1 for atypical.