Differential contribution to gene expression prediction of histone modifications at enhancers or promoters
Fig 5
PE models trained using developmental stages.
(A) Performance of each differentiation PE model on the rest of the developmental stages as compared to the performance over the random models. Performance is represented as Pearson’s correlation (r) between predicted expression and measured expression. Significance was assessed using a paired Student’s t-test of the performance of the models or of the random models paired by a differentiation test set (****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05). (B) Importance of histone modifications for each development PE model. Importance is defined as the contribution of each variable in the linear regression predictive model and corresponds to the absolute value of the t-statistics for each model parameter. Heart10.5, heart tissue from 10.5 embryonic day; Kidney14.5, kidney tissue from 14.5 embryonic day; Liver11.5, liver tissue from 11.5 embryonic day; Lung15.5, lung tissue from 15.5 embryonic day; NeuralTube12.5, neural tube tissue from 12.5 embryonic day.