Differential contribution to gene expression prediction of histone modifications at enhancers or promoters
Fig 3
RNA-seq and ChIP-seq data before and after LOESS normalization.
(A) Raw and normalized expression of 3,277 housekeeping genes along cardiac and neural differentiation from ESCs. (B) Raw and normalized expression of 3,459 bivalent genes along the same time points as A. (C) Raw and normalized H3K4me3 ChIP-seq signal levels at all 2-Kb bins of the genome. (D) Raw and normalized H3K4me3 ChIP-seq signal levels at 3,344 BPs. (E, F), same as C and D, respectively, but for H3K27me3. CM, cardiomyocytes; CN, cortical neurons; CP, cardio precursors; MES, mesoderm; NPC, neural precursors.