Ascension of Chlamydia is moderated by uterine peristalsis and the neutrophil response to infection
Fig 7
Graphical representation of the impact of the immune response and subsequent chlamydial death rate on the proportion of simulations that result in ascension.
The proportion of simulations where the infection ascends was computed (total 252,500 simulations represented in each figure). Each figure shows the proportion of simulations where the infection ascended on the y axis and on the x axis the death rate of EBs and infected cells due to different components of the immune system (represented as broad scales of response). (A) Impact of EB death rate due to the innate immune system on the proportion ascending, (B) Impact of infected cells death rate due to the innate immune system on the proportion ascending, (C) Impact of EB death rate due to the adaptive immune system on the proportion ascending, and (D) Impact of infected cells death rate due to the adaptive immune system on the proportion ascending. These are simulated over a range of infectious loads (10 simulations at each value of infectious load from 1 to 10001 in steps of 100.The solid blue line indicates a loess fit to the proportion of simulations the ascended and the shaded area represents 95% Confidence Intervals of the loess regression. Dots represent simulations at a particular parameter value from a total of 252, 500.