BEEM-Static: Accurate inference of ecological interactions from cross-sectional microbiome data
Fig 3
BEEM-Static robustly filters samples violating modeling assumption in simulated and real datasets.
(A-B) Performance reduction for BEEM-Static (with filters) and the naïve algorithm (without filtering of samples) as the percentage of samples at (A) equilibrium or (B) generated from the main model, decreases. Reduction is measured relative to BEEM-Static with no filters and all data from the model and at equilibrium. Points denote the means while error bars denote the standard deviation across 30 simulations each. (C-D) Principal coordinates plots (Bray-Curtis dissimilarity) representing gut microbiome taxonomic profiles from 4,617 samples. Points represent samples from individuals taking antibiotics (C) or from newborn infants (D), while crosses represent samples from adults who are not undergoing antibiotic treatment. Points that were filtered by BEEM-Static are colored blue and red otherwise.