INTEGRATE: Model-based multi-omics data integration to characterize multi-level metabolic regulation
Fig 2
Experimental metabolic measurements at balanced growth phase.
A) Number of cells in time. B) Protein content in time. C) Correlation plots between protein content and number of cells for experimental observations in the 0–48hrs time windows. D) Dot plot representing the normalized mean (Z-score) of the metabolite abundances within each line (visualized by color) and the fraction of samples of each cell line with the abundance over the mean of all cell lines samples (visualized by the size of the dot). The first five metabolites that better distinguish each cell line from the others, according to t-test p-value, are reported. E) t-SNE dimensionality reduction of intracellular metabolomics profiles. F) Extracellular flux ratios, derived from spent medium measurements.