Ankyrin repeats in context with human population variation
Fig 12
ARDs in complex with substrates.
(A) RFXANK and RFX5 (PDB ID: 3V30) [56]; (B) ANRA2 and HDAC4 (3V31); (C) TNKS2 and ARPIN (4Z68) [59]; (D) TNKS1 and USP25 (5GP7) [60]. UMD positions (red) and UMEs 11, 12 (orange) are conserved across proteins that bind similar substrates (dark cyan). For example, these positions are conserved across TNKS2 and TNKS1, which are known to bind substrates with the motif RXXPDG (purple). Similarly, RFXANK and ANRA2, bind substrates with the motif PXLPX[I/L] (purple). Figure obtained with UCSF Chimera [7].