Ankyrin repeats in context with human population variation
Fig 11
(A) Protein-substrate interactions enrichment plot. Error bars indicate 95% CI of the protein-protein interactions enrichment score (PPIES), i.e., ln (OR). Data points are coloured according to their surface classification (Table 1); (B) D34 region of ANK1 ARD, PDB accession: 1N11 [53]. This structure shows 12 out of the 23 ARs found on this ARD. Residues are coloured according to the PPIES of the alignment column they align to in the MSA. The colour scale goes from blue (depleted in PPIs) to orange (enriched in PPIs) going through white (neutral). From left to right, the whole domain, then the concave, convex and basal surface are coloured. On each of the last three representations, only one surface is coloured. Residues not belonging in that surface are coloured in grey. Overall, the concave surface is coloured in a strong orange colour, indicating its importance in protein binding, whereas the basal one presents a dark blue colour, indicative of its overall depletion in PPIs. Figure obtained with UCSF Chimera [7].