Ankyrin repeats in context with human population variation
Fig 10
(A) Contact map for intra-repeat residue-residue interactions. Cells are coloured according to the probability of observing contact between two positions with the viridis colour palette. Red boxes above axis indicate the location of the secondary structure (SS) elements, α-helices, in the motif; (B) Intra-repeat contacts enrichment plot. Error bars indicate 95% CI of the enrichment score, i.e., ln (OR). Data points are coloured according to their missense enrichment and residue conservation classification (Fig 9); (C) Cluster of intra-repeat contacts between the first and second helices. Residues 5, 6, 9 and 10 in the first helix interact with residues 17, 18, 21 and 22 by forming hydrophobic interactions. These positions are all buried and conserved; (D) Cluster of intra-repeat contacts between the start and end residues of an AR. These interactions are not as specific as the ones in the first cluster and they include diverse positions such as 1, 3, 31 or 33. These are the most frequently observed contacts across all structure displayed in an example repeat. PDB: 5MA3 [14]. Figure obtained with UCSF Chimera [7].