Ankyrin repeats in context with human population variation
Fig 5
Diagram showing the main components of the pipeline.
VarAlign retrieves variants found in human sequences in the MSA from gnomAD. ProIntVar retrieves structures from the PDBe and runs DSSP and Arpeggio to get secondary structure, accessible surface area and inter-atomic contacts information. Everything is mapped back to the residues and MSA columns [40].