Ankyrin repeats in context with human population variation
Fig 4
Overview of the resulting MSA, including the 7,404 ankyrin repeat sequences.
Only columns with occupancy > 0.5% are shown. Sequences are sorted by a tree generated in Jalview using the average distance method and the BLOSUM62 matrix. Columns between 16–17 and after 33 represent insertions in some ankyrin repeats. Red boxes below the overview indicate the location of the secondary structure elements (SS), α-helices in this case, within the alignment. Grey dashed lines represent gaps and are mostly found at low-occupancy columns. Columns are coloured according to the ClustalX colour scheme [34]. Hydrophobic residues are coloured in blue, glycines in orange, prolines in yellow, polar residues in green and unconserved columns are coloured in white. Obtained with Jalview [35].