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Ankyrin repeats in context with human population variation

Fig 2

(A) Trio of ARs from a designed ankyrin repeat protein [14] (PDB: 5MA3). These three ARs display the main interactions responsible for the correct packing of the ARD. Hydrogen bond interactions are depicted by blue lines whereas hydrophobic ones are depicted in orange; (B) Hydrophobic network formed by Leu6 in the hydrophobic core of the domain; (C) Hydrogen bonding network at the β-turn between positions Asp32-Gly2; (D) Inter-repeat hydrogen bonds between conserved Asn29 and Asp27; (E) Thr4 forms three hydrogen bonds with His7. Structure visualization with UCSF Chimera [7].

Fig 2

doi: https://doi.org/10.1371/journal.pcbi.1009335.g002