A probabilistic model for the ultradian timing of REM sleep in mice
Fig 7
Changes in REM sleep regulation between light and dark phase.
(A) Bar plots comparing the percentage of REM, NREM sleep, and wake during the light and dark phase (REM: Welch’s t-test, t = 16.14, p = 3.37e-30; NREM: t-test, t = 20.26, p = 4.53e-38; Wake: t-test, t = -20.79, p = 5.19e-39; nlight = 72, ndark = 35 mice). Error bars, 95% CIs from 1,000 bootstrap iterations. (B) Bar plot comparing the ratio REM/(REM+NREM) for the light and dark phase (t-test, t = 3.17, p = 0.0019, nlight = 72, ndark = 35 mice). Error bars, 95% CIs from 1,000 bootstrap iterations. (C) Pie chart showing the percentage of sequential and single cycles during the dark phase. (D) Comparison of GMM parameters for the light and dark phase (Welch’s t-test with Bootstrap, klong: t = -77.26, p = 0.0; μlong: t = -372.77, p = 0.0; σlong: t = -57.93, p = 0.0; Methods). (E) Comparison of μlong (solid lines), and threshold (Ref., dashed lines) separating the refractory from the permissive period for the light and dark phase. Shadings, 95% CIs obtained from 10,000 bootstrap iterations. (F) Comparison of the CDFs of the GMMs for the light and dark phase shown for 4 different values of REMpre.