Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants
Fig 9
(A) Difference in the occupancies for the open and the closed states for the top 64 mutants with VDS>0.3 (red) and the 20 mutants with lower VDS (blue). Occupancy difference for the WT is represented by the dashed green line. Y-axis based on the transformation of a symmetric logarithmic scale. (B) Two visualizations of the 6VYB structure highlighting the mutations. The bottom 20 mutant positions are marked in two shades of blue, with the darker shade indicating positions in which at least one mutant had an (open–closed) occupancy value smaller than wild type. The top 64 mutant positions are marked in two shades of red, with the darker shade indicating positions in which at least one mutant had an (open–closed) occupancy value higher than wild type.