Modelling conformational state dynamics and its role on infection for SARS-CoV-2 Spike protein variants
Fig 6
Heatmaps representing the values of ΔSvib for the closed structure (A, left-hand section) and for the open structure (A, right-hand section), and the values of VDS (B) for every possible mutant in Spike from positions 14 to 913. Each column represents one of the 20 amino acids (repeated in the left heatmap). Notice that for each position (represented in a row), one particular column represents the value of the WT amino acid found at that position. Higher values of ΔSvib are represented in yellow and lower values in dark purple. Higher values of VDS are represented in red and lower values in blue. The domain structure of Spike is represented in (C) for reference purposes.