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ASCENT (Automated Simulations to Characterize Electrical Nerve Thresholds): A pipeline for sample-specific computational modeling of electrical stimulation of peripheral nerves

Fig 6

Implementation of a human VNS model as studied in Arle et al. 2016 [39].

Top panel: segmented nerve geometry modeled in the original publication and image of FEM produced with ASCENT. As modeled in Arle et al. 2016 [39], the electrode lacks insulation. Bottom panel: heatmaps and recruitment curves for fiber activation thresholds across fiber diameters and pulse widths. We generated the heatmaps using Query’s heatmaps() method. Consistent with our prior modeling studies [10], the heatmaps show that fibers in the same fascicle with the same diameter have nearly identical thresholds. Configuration and input files used to replicate the results are provided in examples/results/arle_2016/.

Fig 6

doi: https://doi.org/10.1371/journal.pcbi.1009285.g006