The evolutionary history of topological variations in the CPA/AT transporters
Fig 7
Change in orientation in broken transporters by shuffling.
(a) Sequence and topology alignments, which shows the high similarity between N-terminal and C-terminal repeats of SBF_like and Mem_trans families and vice versa. All the transmembrane helices are numbered sequentially. (b) Sequence similarity, represented with E-values, between NR-NR, CR-CR and NR-CR repeats of two different families in the BART fold-type are shown. NR and CR refer to the N- and C-terminal repeats respectively. (c) Cartoon representation showing events of shuffling of repeats leading to change in orientation.