The evolutionary history of topological variations in the CPA/AT transporters
Fig 6
Change in orientation in reentrant transporters by internal duplications.
(a) Sequence and topology alignment between transporters from CPA-reentrant fold-type showing the change in orientation. All the transmembrane helices are numbered sequentially and the reentrant helix is denoted as RH. (b) Sequence similarity between N- and C-terminal repeats represented by E-values in different families with fold-types containing symmetric repeat units are shown (c) Reentrant N- and C-terminal core helix motif (d) Cartoon representation showing the events of duplication from C-terminal repeat of reentrant transporter and subsequent internal duplication leading to change in orientation.