The evolutionary history of topological variations in the CPA/AT transporters
Fig 4
Transition and alignments between 2HCT and PSE_1.
a) A “Dotplot” between PSE_1 and 2HCT: The blue lines represent the TM helices and the red one the reentrant helices, the color spectra show the Log of E-value of the alternative alignments. b) The panel shows an all-vs-all distance matrix between the trRosetta models and the 2HCT PDB structure 5a1s. The greyscale indicates the distance between the mutual distances between the protein residues from 4 to 10 Å. b) Schematic representation of the topology of the protein with its corresponding structure below. The TM helices (in-out) and (out-in) are colored white and grey respectively. The reentrant helices after the transition are colored red. The helix 7 that changes position after the transition is colored green. The part of 2HCT putatively lost in the truncation is colored blue. c) Corresponding protein structures.