Bistability in fatty-acid oxidation resulting from substrate inhibition
Fig 7
Model extensions and mFAO bistability.
The computational model was extended with the different reactions indicated in Fig 1 and detailed in S1 Text. A. Activation of MCKAT via reducing the inhibitory effect of p46Shc protein (WT: wild type and ShcKO: 20% residual activity of p46Shc protein. B.The model was extended with PDH and ETC and activation of CPT1 and ETC by SCFA. C and D. The model was extended with ACOT.