Bistability in fatty-acid oxidation resulting from substrate inhibition
Fig 5
Bistability and hysteresis behaviour in mitochondrial fatty acid oxidation when varying selected model parameters.
Simulated uptake fluxes for increasing and decreasing palmitoyl-CoA concentrations. A. [NAD+]:[NADH] ratio varying between 10 and 40, without altering the sum of [NAD+] and [NADH]. B. [FAD]:[FADH2] ratio varying between 0.10 and 0.93. C. Malonyl-CoA varying between 0 and 10 μM. D. Total CoA varying between 2500 and 10000 μM.