Emergence of directional bias in tau deposition from axonal transport dynamics
Fig 6
Tau transport feedback recaptures the directionality of mouse tauopathy models.
(a) The AD-like mouse models explored by [20] exhibit a strong retrograde bias that becomes more pronounced over time, which can be replicated in the two-neuron system with weak anterograde-directed transport feedback (low δ relative to ϵ). (b) The non-AD-like mouse models similarly have a trend towards increasing retrograde bias, although to a lesser extent than the AD-like studies and there is evidence of early anterograde bias, which is captured by fixing both δ and ϵ at high values. For all studies, we first linearly transform the bias parameter, s, used by [20] onto the [−1, 1] scale of our SD bias estimates before plotting. Refer to S2 Table for a full parameterization of both simulations and Methods: Analysis. Studies included: [11, 13, 36, 37].