Emergence of directional bias in tau deposition from axonal transport dynamics
Fig 3
Temporal profiles of somatodendritic tau deposition.
(a) Time course of mean soluble (red) and insoluble (blue) tau deposition in the presynaptic (solid lines) and postsynaptic (dashed lines) SD compartments for each of the previous simulation conditions. (b) Total presynaptic (purple solid line) and postsynaptic (purple dashed line) tau can be used to calculate a net bias at each time point (magenta dotted line; Eq 15). The balance between transport parameters δ and ϵ determines the compartment in which tau preferentially accumulates and if there is a net bias over time. (c) Schematized versions of the end configurations of the system for each parameter regime.