Emergence of directional bias in tau deposition from axonal transport dynamics
Fig 2
Model regimes are determined by tau transport feedback parameters δ and ϵ.
(a) Simulation results where δ = 1 and ϵ = 0.01, which leads to a strong anterograde bias that emerges within hours and persists even at longer time scales. (b) Simulation results where δ = 0.01 and ϵ = 1, which leads to a strong retrograde bias that only emerges at intermediate-to-late time scales. (c) Simulation results where δ = 1 and ϵ = 0.35, which leads to an initial anterograde bias that is counteracted at intermediate time scales, leading to a uniform distribution of tau deposition at steady state.