Emergence of directional bias in tau deposition from axonal transport dynamics
Fig 1
Schematized version of the one-dimensional system that we simulate. We model two distinct species of pathological tau, soluble (red) and insoluble (blue), across within a multi-compartment model mimicking the two-neuron system shown in the top panel. The main biological phenomena captured in this model are diffusion (blue box), active transport (green box), species interconversion through fragmentation and aggregation (purple box), and a diffusion-based barrier to inter-compartmental spread (brown dashed lines).