IUSMMT: Survival mediation analysis of gene expression with multiple DNA methylation exposures and its application to cancers of TCGA
Fig 4
Upset plot and heatmap plot of the P-values (A-F). In the heatmaps of γTE (A) and γDE (C), the color of each box indicates the magnitude of the P-value. The number in the comment part represents the P-value processed by the negative logarithmic transformation. The darker the color, the smaller the P-value. In the Upset plots of γTE, β, γDE, IUT, and IUSMMT, each bar shows the number of shared genes. In these Upset plots, the blue part represents cancer type-specific genes, and the red, green, orange, and purple parts represent genes shared in two, three, four and five types of cancers. (F) The heatmap of the P-values of the 14 overlapped genes across all the cancers. The color of each box indicates the magnitude of the P-value. The number in the comment part represents the P-value processed by the negative log transformation, the darker the color, the smaller the P-value.