IUSMMT: Survival mediation analysis of gene expression with multiple DNA methylation exposures and its application to cancers of TCGA
Fig 3
The QQ plot (A) and the average power curve (B-C) for IUSMMT and IUT. The QQ plot (A) is under the scenario of sparse nulls. The average power curve is calculated when the mediation strength parameter τ2 increases under the sparse alternative (B) and the dense alternative (C). Here, n = 400, β = 0.3, and τ2 = 0.01, 0.02, 0.04, 0.05 or 0.10 at the x-axis. The magnitude of τ2 quantifies the strength of association between DNA methylation CpG sites and gene expression. In B and C, the number of genes (i.e., mediators) was set to 104.