Computational Eurotransplant kidney allocation simulations demonstrate the feasibility and benefit of T-cell epitope matching
Fig 6
PIRCHE-II score distributions in simulations.
The log-transformed PIRCHE-II score distributions resulting from the different ETKAS simulation models. Density plots for the simulations were generated using a Gaussian smoothing kernel. Red lines in graphs A-C represent the PIRCHE-II scores in the ETKAS baseline simulations, the green line in graph A represents the previously reported PIRCHE-II scores as observed in the PROCARE cohort[20], blue lines in graphs B-C represent the PIRCHE-II scores in the PIRCHE-II modified ETKAS simulations for the ETKASPIR-E with priority by HLA match, assignment of points linearly descending, and inclusion of a PIRCHE-II based mismatch probability (MMP) (B), and ETKASPIR-F with priority allocation by PIRCHE-II score, assignment of points linearly descending, and inclusion of a PIRCHE-based MMP (C). Dashed lines indicate the previously reported strata by Lachmann et al. [19].