Computational Eurotransplant kidney allocation simulations demonstrate the feasibility and benefit of T-cell epitope matching
Fig 5
Simulation stability evaluation.
(A) HLA match grade of the ETKAS simulations, year 10 compared to the 1998 observations: JSD = 0.069, p<0.001, year 10 compared to 2015 ETKAS observations: JSD = 0.135, p<0.001. (B) Observed HLA match grade reported by ET annual reports, only ETKAS. (C) Course of the distribution of the countries of origin of virtual individuals. (D) Course of country balance depending on country and simulated allocation models. (E) Number of transplants per country remained stable between the simulated allocations. (F) distribution of recipient age in the individual PIRCHE groups of different simulation allocations.