Computational Eurotransplant kidney allocation simulations demonstrate the feasibility and benefit of T-cell epitope matching
Fig 3
(A) Graphical representation of the distribution of the 400 points for match grade in the PIRCHE-modified models ETKASPIR-B, -C, -D, -E, and -F. (B) Distribution of ETKAS points for HLA MMP on the bootstrapped waiting lists (red curve) shows a benefit for relatively few patients with rare genotypes. Unconverted, the PIRCHE-II risk profile (capped at PIRCHE-II weighted median of 200) assigns more points to average genotypes (blue curve), requiring fitting a polynomial (green curve) to match the regular ETKAS profile.