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Using mobility data in the design of optimal lockdown strategies for the COVID-19 pandemic

Fig 5

Flow diagram of the data-driven optimal control approach.

Starting from a generic-type SEIRD model, we learn optimal model parameters based on mobility/healthcare datasets and Approximate Bayesian Computation. The output is a posterior distribution of model parameters, which is used to generate calibrated SEIRD dynamics and a cost functional accounting both for sanitary and economic costs of a lockdkown. These two ingredients determine the formulation of an optimal control problem, which is solved by means of a global optimization algorithm. The final output of our approach is an optimal lockdown policy which can be recalibrated as new data is fed into the system.

Fig 5

doi: https://doi.org/10.1371/journal.pcbi.1009236.g005