A computational method for identifying an optimal combination of existing drugs to repair the action potentials of SQT1 ventricular myocytes
Fig 7
AP and Ca2+ transient waveforms for hiPSC-CMs, rabbit ventricular CMs and adult human ventricular CMs in the wild type case (solid green), in the SQT1 case (solid red), and in the SQT1 case with the optimal combination of five drugs with the restriction D ≤ min(EC50)/2 from Fig 6 applied (dotted yellow).
Data used in this figure can be found in S1 Data.