A computational method for identifying an optimal combination of existing drugs to repair the action potentials of SQT1 ventricular myocytes
Fig 6
Optimal cost function values obtained when our computational procedure is applied to combinations of an increasing number of drugs applied simultaneously with the goal of repairing the SQT1 mutation in hiPSC-CMs, rabbit ventricular CMs and adult human ventricular CMs.
These computations were done applying the restrictions D ≤ min(EC50)/2 (pink) and D ≤ min(EC50) (red) for the drug doses. Data used in this figure can be found in S1 Data.