A computational method for identifying an optimal combination of existing drugs to repair the action potentials of SQT1 ventricular myocytes
Fig 3
Optimal cost function values obtained by applying our computational procedure to combinations of two drugs, selected for their potential to repair the SQT1 mutation in hiPSC-CMs, rabbit ventricular CMs and adult human ventricular CMs.
The numbers in the upper left to lower right diagonal report the cost function values found in searches for the optimal dose of a single drug. In addition, the pink circles indicate the lowest cost function value obtained in each case.