A computational method for identifying an optimal combination of existing drugs to repair the action potentials of SQT1 ventricular myocytes
Fig 2
Action potentials, Ca2+ transients and IKr currents generated using our models for wild type and SQT1 hiPSC-CMs, rabbit ventricular CMs and adult human ventricular CMs.
Each panel in the upper row shows the action potentials in the wild type and SQT1 cases, and the middle row shows the Ca2+ transients. In the lower row, the IKr current from each action potential simulation is plotted as a function of the membrane potential during the entire AP waveform. Here, the filled circles mark the solution at t = 0 and the arrows indicate the direction with time. Data used in this figure can be found in S1 Data.