Evaluation and comparison of multi-omics data integration methods for cancer subtyping
Fig 9
Influences of different omics data and their integration on cancer subtyping.
(A) Influence of different omic types to different cancers on cancer subtyping. On the radar plot, each quadrilateral represents a cancer type and each vertex of the quadrilateral represents the influence (i.e. Weighted Average Z-score) of a type of omic data with regard to that cancer. (B) Effective combinations of each cancer-method pair. Each vertex in the radar plots represents the weighted average z-score of a specific data combination with respect to a particular pair of cancer and method. In the plots, we use integers 1, 2, 3, and 4 to label the four omics data types mRNA expression, miRNA expression, DNA methylation, and CNV, respectively, so that a data combination can be written as a sequence of digits. For example, the sequence “134” corresponds to the combination of the three data types: mRNA expression, DNA methylation, and CNV. The red circle on each radar plot represents the z-score of zero. Combinations with a positive average weighted z-score are colored red and are considered to be effective for that cancer-method pair. (C) Common effective combinations of cancer types. The effective combinations for most cancer types are colored red.